منابع مشابه
Progress in research into the genes associated with venous thromboembolism.
BACKGROUND Venous thromboembolism (VTE), including both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common, lethal disorder that affects hospitalized and non-hospitalized patients. This study aimed to review the progress in the research into VTE. DATA SOURCES We reviewed the studies about VTE and verified different genetic polymoriphisms of VTE. RESULTS The pathogenesis of ...
متن کاملIdentifying genes for neurobehavioural traits in rodents: progress and pitfalls
Identifying genes and pathways that contribute to differences in neurobehavioural traits is a key goal in psychiatric research. Despite considerable success in identifying quantitative trait loci (QTLs) associated with behaviour in laboratory rodents, pinpointing the causal variants and genes is more challenging. For a long time, the main obstacle was the size of QTLs, which could encompass ten...
متن کامل1990-2000: progress in determining high blood pressure genes.
INTRODUCTION This article attempts to summarise the genetic research that has taken place during the past decade to determine the identity of genes causing high blood pressure. METHODS Candidate gene studies and genome-wide scanning have been the methods primarily employed, and studies have been performed in both experimental models (rats and mice) and human volunteers (sibling-pairs and case...
متن کاملProgress and problems in defining susceptibility genes for rheumatic diseases.
Hypothesis-free genetic mapping of complex disease genes has been relatively unsuccessful to date and the rheumatic diseases are no exception. Weiss and Terwilliger in a recent article asked how many diseases it took to map a gene using single nucleotide polymorphisms (SNPs) w1; see also 2x. This ironic comment was directed at the raising of the SNP to the status of icon and saviour of human ge...
متن کاملIdentifying susceptibility genes of IgA nephropathy: research in progress.
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide and a significant cause of end-stage renal disease [1]. Although dysregulation of mucosal immunity is a notable feature of this disease, the pathogenesis of IgAN remains poorly understood and its treatment is limited. Familial clustering of patients with IgAN suggests a genetic predisposition [2–5]. Rece...
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ژورنال
عنوان ژورنال: Nature
سال: 1967
ISSN: 0028-0836,1476-4687
DOI: 10.1038/214538c0